Due to its central location, Nagpur is a very important railway junction and a transit for almost all the trains that connect the country lengthwise and breadthwise, especially trains connecting India's four major metropolises (Mumbai, Delhi, Chennai, and Kolkota) located in the four corners of the country. The main railway station in Nagpur city is the Nagpur Railway Station, while the much smaller Ajni, Itwari, Kalamna, Kamptee, and Khapri are the other railway stations in the city's vicinity.

Nagpur is also a major junction for roadways as India's two major national highways (Kanyakumari-Varanasi (NH 7) and Hajira-Kolkota (NH-6)) pass through the city. One more highway number 69 connect Nagpur to Obaidullaganj near Bhopal. Nagpur is also at the junction of two Asian Highways namely AH47 Agra,India to Matara, Sri Lanka and AH46 connecting Kharagpur, India to Dhule,India Moreover, Nagpur city has come in the national spotlight recenty for its good roads, which were developed as part of the upgradation and renewal works under Integrated Road Development Project (IRDP), spearheaded by the erstwhile Commissioner of the Corporation Dr. T Chandrashekhar. In another notable development, the Inland Container Depot at Nagpur run by Container Corporation of India (CONCOR) has been the fastest growing inland port in the country in recent years.

Nagpur's Air Traffic Control (ATR) is the busiest in India, with more than 300 international flights flying over the city every day in 2004. Domestic airlines such as Indian Airlines, Jet Airways, Indigo, [goAir] and Air Deccan connect Nagpur with major cities like Mumbai (5 flights daily), Delhi (2 flights daily), Hyderabad (1 flight daily and 1, 4 times a week), and Kolkata (1 flight thrice a week and another twice a week). In October 2005, Nagpur's erstwhile Sonegaon Airport was declared an international airport and was renamed Dr. Babasaheb Ambedkar International Airport. Initial flights between Nagpur and Sharjah were launched by Air Arabia with the intention of tapping the strong

demand for international travel within Central India. In April 2006 Indian Airlines connected Nagpur and Bangkok with a non-stop twice weekly service. Likewise, Qatar Airways has announced that it will start a thrice-weekly service from Nagpur to Doha shortly.

Nagpur is set to be a prominent destination on India's aviation map as the country's first ever Multi-modal International Cargo Hub (MIHAN) was completed on the outskirts of the city in 2006. MIHAN is expected to contribute significantly to the development of the city as well as the economically backward Vidarbha region. Another major impetus to the budding aviation industry in Nagpur is Boeing's decision to set up a $ 185 million maintenance base in the city in 2006.

Airlines flying into the airport include

1. Indian (Bangkok, Delhi, Hyderabad, Mumbai, Raipur)
2. Jet Airways (Delhi, Mumbai)
3. Air Deccan (Hyderabad, Mumbai)
4. Air Sahara (Delhi, Hyderabad)
5. IndiGo Airlines (Kolkata, Mumbai)
6. Kingfisher Airlines (Ahmedabad, Hyderabad)
7. Air Arabia (Sharjah)
8. Qatar Airways (Doha, starts Feb 2007)